Livedoid vasculitis - Vasculite Livedoid
A Vasculite Livedoid (Livedoid vasculitis) hè una malatia cutanea cronica chì si manifesta prevalentemente in donne giovani è di mezza età. Un acronimu utilizatu per discrive e so caratteristiche hè “Ulcera purpurica dolorosa cù un mudellu reticular di l’estremità inferiori” (PURPLE). Hè associatu cù una varietà di malatie, cumpresu l’ipertensione venosa cronica è e varicosità.
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ReferencesLivedoid vasculopathy hè una cundizione rara di a pelle caratterizata da ulcere dolorose chì cuntinuanu à vultà nantu à e gambe inferiori.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy hè una cundizione rara di a pelle chì provoca ulcere ricurrenti in e gambe inferiori, lasciendu cicatrici pallide cunnisciute cum'è atrophie blanche. Ancu se a causa esatta ùn hè ancora chjara, si crede chì l’aumentu di a coagulazione di u sangue (hypercoagulability) sia u fattore principale, cù l’infiammazione chì ghjoca un rolu secundariu. I fattori chì cuntribuiscenu à a coagulazione includenu: deficiency di i pruteni C è S, mutazioni genetiche cum’è u fattore V Leiden, deficiency di antithrombin III, mutazioni di u gene di a protrombina, alti livelli di omocisteina. In e biopsie, a cundizione mostra coaguli di sangue in i vasi, ispessimentu di i muri vascolari è cicatrici. U trattamentu implica un approcciu multi‑pronged chì si focalizza nantu à a prevenzione di i coaguli di sangue cù medicazione cum’è droghi anti‑platelet, diluenti di u sangue è terapia fibrinolitica. Parechji droghi ponu esse aduprati per sta cundizione di a pelle – colchicine è hydroxychloroquine, vasodilatatori, immunosoppressori.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy hè una cundizione rara induve e lesioni si prisentanu nantu à e duie gambe. A furmazione di coaguli di sangue nei vasi sanguini si pensa sia causata da un aumentu di a coagulazione è da una riduzzione di a rottura di i coaguli, inseme à danni à u rivestimentu di u vaso. È più cumune in e femmine, in particulare trà l'età di 15 è 50 anni. Smettere di fumà, curà e ferite, è l'usu di medicazione cum'è diluenti di sangue è droghe antiplatelet sò stati efficace.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
